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KMID : 0361120160300040184
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Korean Journal of Transplantation
2016 Volume.30 No. 4 p.184 ~ p.189
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A Successful Case of a High Anti A/B Antibody Titer ABO Incompatible Kidney Transplantation Patient Who Received a Kidney from a Hepatitis B Carrier
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Lee Jin-Ho
Kim Han-Sae
Lee Dong-Yeol
Oh Joon-Seok
Shin Yong-Hun
Kim Joong-Kyung
Park Jong-Hyun
Hur Kill
Park Jong-In
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Abstract
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Kidney transplantation (KTP) lowers the mortality and morbidity of patients with end-stage renal disease. Post-transplantation infection and antibody mediated rejection (AMR) are the most common complications. Hepatitis B surface antigen (HBsAg) positive carrier donors and high anti A/B antibody titer ABO incompatible KTP could lead to recipient hepatitis B virus (HBV) infection and AMR. Here, we report a case of successful KTP in a 41-year-old male with a high titer of ABO incompatible and HBsAg positive donor. He underwent seven rounds of plasmapheresis, low dose intravenous immunoglobulin and rituximab treatment to inhibit antibody production and remove antibodies from the serum, after which he was administered anti-viral agent for HBV prophylaxis. The recipient maintained successful allograft function for 6 months after transplantation; therefore, we report that desensitization and anti-viral treatment achieved successful outcome in a 1:512 anti A/B antibody titer ABO incompatible and hepatitis B carrier donor KTP.
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KEYWORD
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ABO incompatibility, Hepatitis B surface antigen positive donor, Kidney transplantation
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